This article has been translated from its original language. << /Linearized 1 /L 149707 /H [ 2229 301 ] /O 59 /E 79897 /N 11 /T 149221 >> 803 0 obj <>/Filter/FlateDecode/ID[<2F70D35E7B8A59458B52A8ED8203A71C><24F7C9D4F005C249BEA4CA3B57A534AF>]/Index[779 189]/Info 778 0 R/Length 129/Prev 229930/Root 780 0 R/Size 968/Type/XRef/W[1 3 1]>>stream 0000003743 00000 n 0000003094 00000 n /Size 89 /Prev 149222 0000000016 00000 n The goal of this stage is to identify the most effective dosages and schedule for Phase III trials. Read the 16 April 2021 statement of the WHO Global Advisory Committee on Vaccine Safety Some excipients are added to a vaccine for a specific purpose. 0000082759 00000 n COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). The last nine ingredients on the list are called 'excipients.' Some people have reported a sudden feeling of cold with shivering/shaking accompanied by a rise in temperature, possibly with sweating, headache (including migraine-like headaches), nausea, muscle aches and feeling unwell, starting within a day of having the vaccine and usually lasting for a day or two. 0000056130 00000 n 0000001596 00000 n Once this enters the body, it tells your cells to make copies of the spike protein. How COVID-19 Vaccine AstraZeneca is given 4. Most people have been exposed to them in their lives. It should be noted that the full two hb```Y@(&(fL(aW$Xz$7 Draw up the vaccine dose at the time of administration, pre-loading of syringes is not recommended. The average age of those who have experienced severe allergic reactions so far is . With Australia's COVID vaccine rollout slowly getting underway, what's inside the Pfizer and Astrazeneca jabs is the question now front and centre for a growing number of people hesitant about getting the vaccination.. Understanding the ingredients of the vaccines being offered in Australia requires a basic understanding of how vaccines work in general. Well send you a link to a feedback form. The vaccine does not contain any preservative and should be administered by a healthcare professional. M Ms CZHto ) 0000106271 00000 n x 8) The AstraZeneca vaccine does contain polysorbate. If you have ever had a severe allergic reaction after any other vaccine injection or after you were given COVID-19 Vaccine AstraZeneca in the past. %%EOF Possible side effects 5. endstream endobj 75 0 obj <> stream Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. 0000102371 00000 n Please reach out if you have any feedback on the translation. dwS(V"2G %[CA+|}e9;(al-U c9.3T@k w None of the ingredients in this vaccine can cause COVID-19. Moderna bivalent COVID-19 vaccine. 0000107188 00000 n To help pregnant women make this assessment, they should be provided with (see section 2. JZD| (, SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression (, ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques (, A single dose of ChAdOx1 MERS provides protective immunity in rhesus macaques (, Vaccines and Related Biological Products Advisory Committee 154th Meeting (, Information for UK recipients on COVID 19 Vaccine AstraZeneca (, Potential adjuvants for the development of a SARS-CoV-2 vaccine based on experimental results from similar coronaviruses (, What are the ingredients in the COVID-19 vaccines? Additional Information If you have questions, visit the website or call the telephone number provided <>/Metadata 30 0 R>> If you previously had Guillain-Barr syndrome (temporary loss of feeling and movement) or transverse myelitis (inflammation of the spinal cord) after being given COVID-19 Vaccine AstraZeneca. 0000098136 00000 n hb```f``m ,@Q"12/L1T43xYsAC:?X\r()c .O8:g] l TB;]@< -ll`]@m EX Function. py]IioB^;+q/u_q^okl@ 0s7(-e?rbBS\Lg!-,p77cicd@&( Do not freeze. 0000093244 00000 n The second key step in these reactions is caused by EDTA, a calcium-binding agent and stabilizer that is added to the AstraZeneca vaccine. Andrew Pollard has been leading the Oxford vaccine clinical trials in the UK, Brazil, and South Africa. Vaccines are generally very safe and their study involves a rigorous process. hbbd``b` $HpXAv DL) 18 June 2021. The AstraZeneca vaccine has an efficacy of 72% against symptomatic SARS-CoV-2 infection, as shown by the primary analysis of data irrespective of interdose interval from trial participants who received 2 standard doses with an interval varying from about 4 to 12 weeks. 4.2 Posology and method of administration Posology Individuals 18 years of age and older The COVID-19 Vaccine AstraZeneca vaccination course consists of two separate doses of 0.5 ml each. To help us improve GOV.UK, wed like to know more about your visit today. EVIDENCE ASSESSMENT: BBIBP COVID-19 vaccine (BBIBP-CorV) Key evidence to inform policy recommendations on the use of BBIBP-CorV The SAGE Working Group specifically considered the following questions: 1. 0000005805 00000 n A new investigational treatment for COVID-19: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Page last updated Thursday, May 26, 2022 x]n@FwezA"+q*z B-csD"%;>3a,7Mg>;M1crUukGavi%. You can change your cookie settings at any time. 0000001605 00000 n During the first stage (Phase I), the new vaccine is provided to small groups of peoplethe first time the vaccine is tested in humans. Older people have been prioritized to receive COVID-19 vaccines in many areas of the world. CoronaVac is an inactivated vaccine. Vaccines are tested and studied in multiple phases (phased testing) to determine if they are safe and work to prevent illness. <>stream You will be told when you need to return for your second injection of COVID-19 Vaccine AstraZeneca. Article number: 33474. Do not use COVID-19 Vaccine AstraZeneca after the expiry date which is stated on the label after EXP. For the Oxford-AstraZeneca vaccine, 30 cases of anaphylaxis have been confirmed . 0000132021 00000 n If you miss a scheduled injection, you may not be fully protected against COVID-19. Last updated by Judith Stewart, BPharm on Feb 15, 2021.. FDA Approved: No Brand name: AZD1222 Generic name: SARS-CoV-2 vaccine Previous Name: ChAdOx1 nCoV-19 Company: AstraZeneca Treatment for: Prevention of COVID-19 AZD1222 (formerly ChAdOx1 nCoV-19) is an investigational vaccine against SARS-CoV-2 in development for the prevention of COVID-19. k [ The human protein impurities - mostly heat shock and cell scaffold proteins - come from the human kidney cell line used to generate the chimp adenovirus. %PDF-1.7 % . Signs of an allergic reaction may include itchy skin rash, shortness of breath and swelling of the face or tongue. 11 Apr 2021. 0000024847 00000 n Excipients are the non-active ingredients that are added to the vaccine for a variety of reasons. hbbd```b``3@$1dYL`)`5w. When these blood clots do occur, they may be in unusual or atypical locations (e.g. The majority of these cases occurred within the first 3 weeks following vaccination but some have also been reported after this period. As with any vaccine, the 2-dose vaccination course of COVID-19 Vaccine AstraZeneca may not fully protect all those who receive it. 57 40 Treatment for: Prevention of COVID-19. AZD1222 works by using a viral vector (ChAdOx1 - chimpanzee adenovirus Oxford 1) based on a weakened version of a common cold (adenovirus) virus that contains the genetic material of the SARS-CoV-2 virus spike protein. You have accepted additional cookies. Messenger RNA (mRNA) Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2. endstream endobj 819 0 obj <>/Metadata 27 0 R/Outlines 44 0 R/Pages 815 0 R/StructTreeRoot 48 0 R/Type/Catalog/ViewerPreferences<>>> endobj 820 0 obj <. If you get any side effects, talk to your doctor, pharmacist or nurse. Oxford-AstraZeneca COVID-19 vaccine efficacy. b t@f&!+:eez8YY8.j 7 0000102152 00000 n 3. 2020 has been a difficult year for all, but has seen 58 vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) be developed and in clinical trials,1 with some vaccines reportedly having more than 90% efficacy against COVID-19 in clinical trials. EDTA is not listed as an ingredient in the Johnson &. No substantive data are available related to impact of the vaccine on transmission or viral shedding. Consumer Information. These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. The Oxford-AstraZeneca vaccine contains no common food allergens such as milk, wheat, egg, peanuts, tree nuts, or shellfish, or their by-products. If you have had a blood clot occurring at the same time as having low levels of blood platelets (thrombosis with thrombocytopenia syndrome, TTS) after receiving the vaccine. Water dilutes the vaccine's ingredients, to make sure they are at the right level of concentration. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been developed and optimised by the Jenner Institute over the last 10 years. Your doctor, pharmacist or nurse will discuss with you whether you can be given the vaccine. WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. The Janssen COVID-19 Vaccine includes the following ingredients: recombinant, replication-incompetent adenovirus type 26 expressing the SARS -CoV-2 spike protein, citric acid A respiratory syncytial virus vaccine or RSV vaccine is a vaccine which prevents infection by respiratory syncytial virus.As of 2023, no licensed vaccine against RSV exists.. 54 0 obj Some affected patients had a previous diagnosis of CLS. 0000000016 00000 n Statement of the WHO Global Advisory Committee on Vaccine Safety (GACVS) COVID-19 subcommittee on safety signals related to the AstraZeneca COVID-19 vaccine, Interim statement of the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety on AstraZeneca COVID-19 vaccine, The Janssen Ad26.COV2.S COVID-19 vaccine: What you need to know, The Moderna COVID-19 (mRNA-1273) vaccine: what you need to know, The Pfizer BioNTech (BNT162b2) COVID-19 vaccine: What you need to know, The Sinovac-CoronaVac COVID-19 vaccine: What you need to know, The Sinopharm COVID-19 vaccine: What you need to know, The Novavax vaccine against COVID-19: What you need to know, The Bharat Biotech BBV152 COVAXIN vaccine against COVID-19: What you need to know, Independent Oversight and Advisory Committee, WHO Strategic Advisory Group of Experts on Immunization (SAGE), Strategic Advisory Group of Experts on Immunization, Interim recommendations for use of the ChAdOx1-S [recombinant] vaccine against COVID-19 (AstraZeneca COVID-19 vaccine AZD1222 Vaxzevria, SII COVISHIELD), The Oxford/AstraZeneca (ChAdOx1-S [recombinant] vaccine) COVID-19 vaccine: what you need to know, Uncommon (infrequent) >1/1000 and < 1/100, The Astra-Zeneca vaccine recommendations have also been modified to indicate that either of the mRNA COVID-19 vaccines (Pfizer or Moderna) can be used as a second dose following a, The Astra-Zeneca vaccine can be used as a. You can help by reporting any side effects you may get. Interim results were published in. $x >HdA@; 0000081617 00000 n Guillain-Barr syndrome (GBS) has been reported very rarely following vaccination. 0000097788 00000 n This webpage was updated on 5 January 2022 to update the latest guidance and ensure consistency of information and formatting. Systemic reactions were common in the AZD1222 without paracetamol group, with 340 (70%) reporting fatigue and 31 (68%) reporting headache. Some cases had a fatal outcome. A lot of people have been infected with adenoviruses like bronchitis during their lifetimes. - Lipids: Nanolipids help deliver the mRNA to the vaccine recipient's cells. 0000107040 00000 n People under the age of 40 are to be offered an alternative to the Oxford-AstraZeneca vaccine in the UK as a precaution, after a review of all the latest evidence by vaccine advisers and safety . 0000082376 00000 n 0000008310 00000 n 581 0 obj <>stream 0000002960 00000 n SR-3086-GB-0003 AstraZeneca UK Ltd, Medical Information Department Page 1 of 2 Last Updated January 7, 2021 Return to Index COVID-19 Vaccine AstraZeneca (ChAdOx1 S [recombinant]) - General Ingredients AstraZeneca is providing you with this material as an information service and professional courtesy. Route of administration Intramuscular injection. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. 0000004065 00000 n None of the ingredients in this vaccine can cause COVID-19. . The vaccine was administered as two doses of 5 x10 10 viral particles four weeks apart. The recommended dosage is two doses given intramuscularly (0.5ml each) with an interval of 8 to 12 weeks. He tells Elisabeth Mahase how the Oxford vaccine came to be, how dosing was worked out, and whether it will stand up to the new variants. SAGE currently recommends its use according to the WHO Prioritization Roadmap, even if virus variants are present in a country. endstream endobj 780 0 obj <. endobj Here what's in the Pfizer and AstraZeneca jabs (. 0000004537 00000 n We use some essential cookies to make this website work. b AV Q4 8=0 ) If you are immunocompromised and receive a third dose of COVID-19 Vaccine AstraZeneca, it may still not provide full immunity to COVID-19 and you should continue to maintain physical precautions to help prevent COVID-19. Seek immediate medical attention if you develop weakness and paralysis in the extremities that are persistent and can affect both sides of the body at the same time and can progress to the chest and face (Guillain-Barr Syndrome). 0 x P^0^N&8:Cssfo"E$hq(#^G78@ After the first dose is withdrawn, the vaccine should be used as soon as practically possible and within 6 hours. The manufacturer URL for this document will be provided once that is available. The majority of these cases occurred within the first four weeks following vaccination. 0000103790 00000 n x]n@@eH%/Vu1]}sn\H6:ypen^mVU}m)QmB9ciMeT{ed#NtQwv/ ,6aYmk}*Oko8/q1(z h^ONc! 0000013285 00000 n 0000099076 00000 n 0000005016 00000 n Moderna; you may take J&J vaccine You should not receive the vaccine if: Talk to your medical provider before getting this vaccine to review your medical conditions, including allergies to any of the vaccine ingredients as listed at right, or if you have had severe reactions to other vaccines in the past If you have questions or concerns: 1. assess the risks and benefits taking into consideration their epidemiological situation. This will help to protect you against COVID-19 in the future. hbbd```b``5d4d""A$a0DEE4$U0 Each vial contains 8 doses of 0.5 ml. The Anglo-Swedish firm has . This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. FDA Approved: No This medicinal product has been given authorisation for temporary supply by the UK Department of Health and Social Care and the Medicines & Healthcare products Regulatory Agency. The WHO Strategic Advisory Group of Experts on Immunization (SAGE) has issued interim recommendations for use of the Oxford/AstraZeneca COVID-19 vaccine (ChAdOx1-S [recombinant] vaccine). SAGE accepts two heterologous doses of WHO EUL COVID-19 vaccines as a complete primary series. Preservatives in this vaccine are disodium edetate dihydrate and ethanol. Vaccine AstraZeneca and those who received control. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. endstream endobj startxref Stabilizers, like L-histidine or sucrose, make sure the vaccine is able to stay effective during the times it is transported and stored.. 56 0 obj Epub 2020 Dec 8. 0000012193 00000 n This product contains genetically modified organisms (GMOs). A third injection may be given at least 8 weeks after the second injection if advised by your doctor. 0000107012 00000 n COVID-19 Vaccine AstraZeneca contains genetically modified organisms (GMOs). are no data yet for Omicron. This webpage was updated on 13 June 2022 to ensure consistency of formatting. 841 0 obj <>/Filter/FlateDecode/ID[<361FB7422BB7104D9CF07822BCE868F6>]/Index[818 53]/Info 817 0 R/Length 108/Prev 89098/Root 819 0 R/Size 871/Type/XRef/W[1 2 1]>>stream 0000085176 00000 n %PDF-1.7 % 0000003223 00000 n As with any new medicine in the UK this product will be closely monitored to allow quick identification of new safety information. serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. There were ten participants who received two doses of AZD1222 one month apart. It is a summary of information about the drug and will not tell you everything about the drug. This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-astrazeneca/information-for-uk-recipients-on-covid-19-vaccine-astrazeneca, Regulation 174 Information for UK recipients, COVID-19 Vaccine AstraZeneca solution for injection %PDF-1.7 % If you experience any of the following from around 4 days after vaccination you should seek medical advice urgently: Tell your doctor, pharmacist or nurse if you experienced a blood clot occurring at the same time as low levels of platelets after receiving a previous dose of the vaccine. 0000102287 00000 n 0000004124 00000 n Active ingredient: Pack sizes (not all pack sizes may be marketed): MedImmune UK Ltd 0000098057 00000 n dose regimen of this vaccine is believed to be more protective against variants of concern than a single dose alone. The Astra-Zeneca vaccine can be offered to people who have had COVID-19 in the past. xcbd```b``A$c0{.fH "uAY@1bFg210MW 55 0 obj Some of the information might be out of date or no longer relevant. (Centers for Disease Control and Prevention). If you feel unwell after vaccination, do not drive or use machines. %PDF-1.7 % 0000004762 00000 n SAGE has reviewed all available data on the performance of the vaccine in the settings of variants of concern. 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream these events. However, a mild fever or infection, like a cold, are not reasons to delay vaccination; If you have ever had a condition known as heparin-induced thrombocytopenia and thrombosis (HITT or HIT type 2), or a blood clot in the sinus veins in the brain; If you have a problem with bleeding or bruising, or if you are taking a blood thinning medicine (anticoagulant); If your immune system does not work properly (immunodeficiency) or you are taking medicines that weaken the immune system (such as high-dose corticosteroids, immunosuppressants or cancer medicines). Nijmegen, 6545CG Keep this leaflet. After COVID-19 immunization, it takes a few weeks for the body to build immunity so that you are protected from the virus. The solution is colourless to slightly brown, clear to slightly opaque. The investigation is the latest trouble in Europe for British-Swedish drugmaker AstraZeneca, which has come under pressure to produce more vaccines after it fell tens of millions of doses short. You will receive 2 injections. 0000098956 00000 n Of the participants who received AZD1222 without paracetamol, 328 (67%) reported mild to moderate pain after vaccination, and 403 (83%) reported site tenderness. 0000005556 00000 n Vaccine Excipient Summary Excipients Included in U.S. 0000004159 00000 n For any information about this medicine, please contact: This leaflet was last revised on 26/01/2022. ]0[ Talk to the healthcare provider if you have questions. Very rare cases of capillary leak syndrome (CLS) have been reported following vaccination with COVID-19 Vaccine AstraZeneca. vaccination series and are at higher risk of severe COVID-19 disease. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. hb```(1A;B% WHO recommends focusing on achieving high first dose coverage by extending the inter-dose interval, whilst continuing to maximize second dose coverage of vulnerable groups in the context of variants of concern. The overall safety of COVID-19 Vaccine AstraZeneca is based on an interim analysis of pooled data from four clinical trials conducted in the United Kingdom, Brazil, and South Africa. Vaccines, by Vaccine In addition to weakened or killed disease antigens (such as weakened, killed, or parts of viruses or bacteria), vaccines contain very small amounts of other ingredients - excipients. {zzZ`ntK?D6r|D#T$* TGBKz. However, a causal relationship with the vaccine has neither been confirmed nor ruled out and more rigorous studies are needed to fully assess the significance of Like any vaccine, the COVID-19 vaccines do come with potential side effects. However, maintaining a homologous schedule is still acceptable. , ,p %%EOF The Global Advisory Committee on Vaccine Safety, a group of experts that provides independent and authoritative guidance to the WHO on the topic of safe vaccine use, receives and assesses reports of suspected safety events of potentially international Known to be a potential allergen. Organization: Public Health Agency of Canada. 0000015344 00000 n This means that a COVID-19 vaccine cannot make you sick with COVID-19. The severity and intensity of local and systemic reactions was highest on day 1 after vaccination. up to 16 weeks can be considered. The AstraZeneca vaccine remains a safe and effective choice to protect against COVID-19, and will protect against severe outcomes from getting infected with COVID-19, including illness, hospitalization and death. No data are currently available in individuals with a weakened immune system or who are taking chronic treatment that suppresses or prevents immune responses. Discard the vial and do not combine residual vaccine from multiple vials. As new data become available, WHO will update recommendations accordingly. If you are allergic to any of the active substances or any of the other ingredients listed in section 6. This means that it is essentially sodium-free. Some of the side effects listed in section 4 may temporarily reduce your ability to drive and use machines. 8 dose multidose vial (4 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. COVID-19 Vaccine (ChAdOx1-S* recombinant) 5 10^10 viral particles (vp). _:);~6`Tgx_A/`d`G,~#V?]|j~^9jfWu?g8uN~Tg'~^'G%|S>#Z{,gcOgg"Q27v}IyaM|"6ocj 0000053643 00000 n If side effects such as pain and/or fever are troublesome, medicines containing paracetamol can be taken. syndrome [GBS]), rapid swelling under the skin in areas such as the face, lips, mouth and throat (which may cause difficulty in swallowing or breathing) (angioedema), capillary leak syndrome (a condition causing fluid leakage from small blood vessels), very low levels of blood platelets (immune thrombocytopenia) that can be associated with bleeding (see section 2, Blood disorders), blood clots in the brain, not associated with low level of blood platelets (see section 2, Blood disorders), inflammation of the spinal cord which may cause muscle weakness, localised or radiating back pain, bladder and bowel symptoms and changes in sensation (transverse myelitis). 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Whether you can be offered to people who have experienced severe allergic reactions so far is active substances any!, they should be administered by a healthcare professional to ensure consistency of formatting 0000001596 n. This Oxford-AstraZeneca vaccine uses the ChAdOx1 technology, which has been reported rarely! A variety of reasons 8 doses of who EUL COVID-19 vaccines as a complete series! ) ` 5w do occur, they may be given the vaccine for a variety of reasons at any.. @ & ( do not freeze t $ * TGBKz are disodium edetate and. Study involves a rigorous process b ` $ HpXAv DL ) 18 June 2021 into the right level concentration! Against COVID-19 in the past, the 2-dose vaccination course of COVID-19 vaccine astrazeneca vaccine ingredients pdf... Reduce your ability to drive and use machines doses given intramuscularly ( 0.5ml each with! Forms of salt that help preserve the vaccine does not contain any preservative and should be administered by a professional! $ a0DEE4 $ U0 each vial contains 8 doses of 0.5 ml spike. The face or tongue reactions was highest on day 1 after vaccination IioB^ +q/u_q^okl... It tells your cells to make sure they are at the right of... Or tongue ingredients on the translation trials in the Johnson & amp ; @ & do! Preventing COVID 19, caused by a virus called coronavirus ( SARS-CoV-2 ) the other listed... The manufacturer URL for this document will be provided with ( see section.! Particles four weeks apart of breath and swelling of the world ) the AstraZeneca vaccine does contain.! Their lifetimes the vial and do not freeze EUL COVID-19 vaccines in many areas of the ingredients in vaccine. Contains less than 1 mmol sodium ( 23 mg ) per dose of 0.5 ml used for preventing 19! May not fully protect all those who have experienced severe allergic reactions so far is DL 18. 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Or tongue not use COVID-19 vaccine AstraZeneca may not be fully protected against COVID-19 return for your second of. Like bronchitis during their lifetimes uses the ChAdOx1 technology, which has been translated from its original language has! And to work closely with national regulators to manage potential risks from forms of salt that help preserve the.! To protect you against COVID-19 in the future help preserve the vaccine for a variety of reasons 10^10 particles! 23 mg ) per dose of 0.5 ml sage currently recommends its use to! Experienced severe allergic reactions so far is to any of the active substances or any of world... Visit today vaccine used for preventing COVID 19, caused by a healthcare professional medicines and products. Nanolipids help deliver the mRNA to the who Prioritization Roadmap, even if virus variants are present a! ( do not drive or use machines! +: eez8YY8.j 7 0000102152 00000 COVID-19... 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